Small subgroup of aggressive, highly proliferative prostatic carcinomas defined by p53 accumulation.

doi:10.1093/jnci/84.11.883

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Article

Small subgroup of aggressive, highly proliferative prostatic carcinomas defined by p53 accumulation.

Journal of the National Cancer Institute - 3 Jun 1992

Visakorpi T, Kallioniemi O P, Heikkinen A, Koivula T, Isola J

Abstract excerpt

BACKGROUND: Mutations in the p53 gene resulting in the accumulation of altered p53 proteins with prolonged half-life have been found in a large variety of human malignancies. PURPOSE: We studied the significance of p53 protein accumulation in prostatic carcinoma. METHODS: The material consisted of 137 paraffin-embedded, primary prostatic carcinomas. Accumulation of p53 protein was studied by immunohistochemical...

Topics

Aged
Antibodies
Biomarkers, Tumor
DNA, Neoplasm
Flow Cytometry
Follow-Up Studies
Genes, p53
Humans
Immunohistochemistry
Male
Mutation
Nuclear Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prognosis

Proliferating Cell Nuclear Antigen

Prostatic Neoplasms

Retrospective Studies

Time Factors

Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 1350643
DOI: 10.1093/jnci/84.11.883

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1350643-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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