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Article

Small subgroup of aggressive, highly proliferative prostatic carcinomas defined by p53 accumulation.

Journal of the National Cancer Institute - 3 Jun 1992

Visakorpi T, Kallioniemi O P, Heikkinen A, Koivula T, Isola J

Abstract excerpt

BACKGROUND: Mutations in the p53 gene resulting in the accumulation of altered p53 proteins with prolonged half-life have been found in a large variety of human malignancies. PURPOSE: We studied the significance of p53 protein accumulation in prostatic carcinoma. METHODS: The material consisted of 137 paraffin-embedded, primary prostatic carcinomas. Accumulation of p53 protein was studied by immunohistochemical...

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Source

Identifiers

PMID: 1350643
DOI: 10.1093/jnci/84.11.883

Genes

PCNA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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