Article
Increased p53 mutation frequency during tumor progression--results from a breast cancer cohort.
Cancer research - 15 Nov 2001
Norberg T, Klaar S, Kärf G, Nordgren H, Holmberg L, Bergh J
Abstract excerpt
The mutational patterns of the p53 gene for exons 4-9 were analyzed in 30 recurring tumors compared with the p53 status of the corresponding 30 primary breast cancers. The prevalence of p53 mutations was higher, although not statistically significant (P = 0.07), in the evaluable recurring tumors compared with the corresponding primaries, 12 of 29 (41%) versus 7 of 30 (23%). Twenty-one of the patients had...
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