Article
Evidence for a second tumor suppressor gene on 17p linked to high S-phase index in primary human breast carcinomas.
Cancer genetics and cytogenetics - 1 Sept 1994
Merlo G R, Venesio T, Bernardi A, Cropp C S, Diella F, Cappa A P, Callahan R, Liscia D S
Abstract excerpt
The short area of chromosome 17 is a frequent target for deletions in human tumors, including breast cancer. We have investigated by restriction fragment polymorphism analysis the pattern of loss of heterozygosity (LOH) at four loci on 17p13.1-17pter in a panel of 110 primary human breast carcino...
Topics
- Alleles
- Breast Neoplasms
- Chromosome Deletion
- Chromosomes, Human, Pair 17
- Genes, Tumor Suppressor
- Genes, p53
- Heterozygote
- Humans
- Point Mutation
- Polymerase Chain Reaction
- S Phase