Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of p53 gene mutation by rapid PCR-SSCP and its association with poor survival in breast cancer.

International journal of cancer - 19 Dec 1997

Soong R, Iacopetta B J, Harvey J M, Sterrett G F, Dawkins H J, Hahnel R, Robbins P D

Abstract excerpt

We examined the association between mutation of the p53 gene and survival in a large cohort of breast cancer patients. Using a rapid, non-isotopic single-strand conformation polymorphism (SSCP) method we screened for mutations in exons 4-10 of the p53 gene in 375 primary breast cancers from patie...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Analysis of Variance
Breast Neoplasms
Exons
Female
Genes, p53
Humans
Middle Aged
Multivariate Analysis
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Polymorphism, Single-Stranded Conformational

Prognosis

Source

Identifiers

PMID: 9421363
DOI: 10.1002/(sici)1097-0215(19971219)74:6<642::aid-ijc15>3.0.co;2-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9421363-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of p53 gene mutation by rapid PCR-SSCP and its association with poor survival in breast cancer.PMID 9421363Read ↗

Routine analysis of p53 mutation in clinical breast tumor specimens using fluorescence-based polymerase chain reaction and single strand conformation polymorphism.Semantic proximity Read ↗

Analysis of p53 gene mutation by polymerase chain reaction-single strand conformation polymorphism provides independent prognostic information in node-negative breast cancer.Semantic proximity Read ↗

Detection of mutations and polymorphisms in the p53 tumor suppressor gene by single-strand conformation polymorphism analysis.Semantic proximity Read ↗

TP53 and MYC gene alterations independently predict poor prognosis in breast cancer patients.Semantic proximity Read ↗

p53 gene mutations and steroid receptor status in breast cancer. Clinicopathologic correlations and prognostic assessment.Semantic proximity Read ↗

Mutation detection by highly sensitive methods indicates that p53 gene mutations in breast cancer can have important prognostic value.Semantic proximity Read ↗

Mutations in p53, p53 protein overexpression and breast cancer survival.Semantic proximity Read ↗

A rapid and nonisotopic method for the screening and sequencing of p53 gene mutations in formalin-fixed, paraffin-embedded tumors.Semantic proximity Read ↗

Prognostic significance of mutations to different structural and functional regions of the p53 gene in breast cancer.Semantic proximity Read ↗

Prognostic significance of p53 gene alterations in node-negative breast cancer.Semantic proximity Read ↗

Correlation between mutation in P53, p53 expression, cytogenetics, histologic type, and survival in patients with B-cell non-Hodgkin's lymphoma.Semantic proximity Read ↗

In primary human breast carcinomas mutations in exons 5 and 6 of the p53 gene are associated with a high S-phase index.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.