p53 mutation is a common genetic event in ovarian carcinoma.

Article

p53 mutation is a common genetic event in ovarian carcinoma.

Cancer research - 1 May 1993

Milner B J, Allan L A, Eccles D M, Kitchener H C, Leonard R C, Kelly K F, Parkin D E, Haites N E

Abstract excerpt

Using the single-strand conformational polymorphism technique, we have screened 66 malignant ovarian tumors for p53 mutation in exons 5 to 8. Thirty-four of the tumors demonstrated a single-strand conformational polymorphism band shift in this region of the gene, including 6 in exon 5, 7 in exon...

Topics

Base Sequence
Carcinoma
Electrophoresis, Agar Gel
Exons
Female
Humans
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Ovarian Neoplasms
Tumor Suppressor Protein p53

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