Article
Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer.
Journal of the National Cancer Institute - 3 Feb 1993
Allred D C, Clark G M, Elledge R, Fuqua S A, Brown R W, Chamness G C, Osborne C K, McGuire W L
Abstract excerpt
BACKGROUND: The p53 (also known as TP53) tumor suppressor gene encodes for a nuclear phosphoprotein thought to regulate proliferation of normal cells. Most p53 mutations result in a nonfunctional protein that accumulates in tumor cell nuclei. These common mutations appear to be involved in the development and/or progression of several neoplastic diseases including human breast cancer. PURPOSE: Our purpose was to...
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