Article
p53 mutations in ovarian cancer: a late event?
Oncogene - 1 Sept 1991
Mazars R, Pujol P, Maudelonde T, Jeanteur P, Theillet C
Abstract excerpt
Using a combination of polymerase chain reaction and single-strand conformation polymorphism techniques we analyzed 34 ovarian cancer samples (30 primary tumors and four matched metastases) for the presence of mutations in exons 5, 6, 7, 8 and 9 of the p53 gene. Mutations in this portion of the g...
Topics
- Amino Acid Sequence
- Base Sequence
- Codon
- Exons
- Female
- Genes, Tumor Suppressor
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Neoplasm Metastasis
- Oligodeoxyribonucleotides
- Ovarian Cysts
- Ovarian Neoplasms
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Proto-Oncogenes