Article
Oncogenic aberrations in the p53 pathway are associated with a high S phase fraction and poor patient survival in B-cell Non-Hodgkin's lymphoma.
International journal of cancer - 20 Jul 2000
Stokke T, Galteland E, Holte H, Smedshammer L, Suo Z, Smeland E B, Børresen-Dale A L, DeAngelis P, Steen H B
Abstract excerpt
The implications of aberrations in the p53 pathway for induction of apoptosis and regulation of S phase entry, and for patient survival, were investigated in 83 B-cell Non-Hodgkin's lymphomas. Eight cases had missense mutations in exons 5, 7, 8 and 9 as revealed by constant denaturant gel electrophoresis and sequencing. Fifteen cases had lost 1 TP53 allele as revealed by fluorescent in situ hybridization and...
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