Article
[Allelic losses of tumor suppressor gene on chromosome 17 in ovarian cancer].
Nihon Sanka Fujinka Gakkai zasshi - 1 May 1993
Sakamoto T, Ogino M, Yamamoto T, Mori H, Okinaga S, Sonoda T, Ueda K, Obi S, Kobayashi T
Abstract excerpt
Twenty-one human ovarian epithelial carcinomas (13 serous, 3 mucinous, 2 endometrioid and 3 clear cell type) were examined for allelic losses of p53 tumor suppressor gene, pYNZ22 or pTHH59 on chromosome 17. High-molecular-weight DNA was extracted from ovarian tumor tissues and normal ones obtained from the same patients, and was subjected to Southern blot analysis. The filters were hybridized with p53 cDNA probe...
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