Overexpression of the p53 protein and allele loss at 17p13 in ovarian carcinoma.

doi:10.1038/bjc.1992.8

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Article

Overexpression of the p53 protein and allele loss at 17p13 in ovarian carcinoma.

British journal of cancer - 1 Jan 1992

Eccles D M, Brett L, Lessells A, Gruber L, Lane D, Steel C M, Leonard R C

Abstract excerpt

Mouse monoclonal antibodies PAb 240 and PAb 1801 which specifically immunoprecipitate p53 protein, were used to examine 27 fresh ovarian tumours (16 serous adenocarcinomas, six endometrioid carcinomas, one mucinous adenocarcinoma, one mucinous borderline tumour and three benign adenomas). Eleven out of 16 (69%) serous adenocarcinomas and one endometrioid tumour showed positive staining with one or both antibodies...

Topics

Adenocarcinoma
Adenocarcinoma, Mucinous
Adenoma
Alleles
Antibodies, Monoclonal
Chromosome Banding
Chromosome Deletion
Chromosomes, Human, Pair 17
Endometrial Neoplasms
Female
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, p53

Heterozygote

Humans

Immunohistochemistry

Ovarian Neoplasms

Restriction Mapping

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 1310251
DOI: 10.1038/bjc.1992.8
PMCID: PMC1977350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1310251-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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