Article
Allelic loss in ovarian cancer.
International journal of cancer - 19 Jun 1993
Yang-Feng T L, Han H, Chen K C, Li S B, Claus E B, Carcangiu M L, Chambers S K, Chambers J T, Schwartz P E
Abstract excerpt
Loss of heterozygosity (LOH) was examined at 86 loci distributed on every chromosomal arm in 50 human ovarian tumors. Frequent allele losses were observed on chromosomes 13q (42%), 17p (42%), 17q (45%), and Xp (41%). Deletion mapping on chromosome 17 revealed a candidate gene on the long arm distal to D17S41/S74 for ovarian cancer which is distant from the locus for early onset breast cancer. LOH on chromosome...
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