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Article

Involvement of p53 gene in the allelic deletion of chromosome 17p in human ovarian tumors.

Anticancer research - 1 Jan 2000

Tsao S W, Mok C H, Oike K, Muto M, Goodman H M, Sheets E E, Berkowitz R S, Knapp R C, Lau C C

Abstract excerpt

Previous reports have shown that one copy of the chromosome 17 was frequently lost in human ovarian cancers (1). The position of the allelic deletion has not been mapped and involvement of p53 gene has not been determined. In this study, we have shown that in human ovarian carcinoma, the commonest region of allelic loss in chromosome 17p is 17p 13.3 (65%) and 17p13.1 (63.7%; 6 out of 9 informative cases). Allelic...

Topics

Alleles
Chromosome Banding
Chromosome Deletion
Chromosomes, Human, Pair 17
DNA Probes
Female
Genes, p53
Humans
Neoplasm Staging
Ovarian Neoplasms

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PMID: 1776830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1776830-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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