Article
Frequent allelic losses and mutations of the p53 gene in human ovarian cancer.
Cancer research - 1 Oct 1991
Okamoto A, Sameshima Y, Yokoyama S, Terashima Y, Sugimura T, Terada M, Yokota J
Abstract excerpt
The p53 gene on chromosome 17p is considered to be a tumor suppressor gene, and frequent mutations of the p53 gene have been found in a wide variety of human cancers. We examined 31 ovarian cancers for allelic losses and mutations of the p53 gene by polymerase chain reaction-single strand conformation polymorphism analysis as well as restriction fragment length polymorphism analysis. Allelic loss of the p53 gene...
Topics
- Base Sequence
- Chromosomes, Human, Pair 17
- Cloning, Molecular
- Electrophoresis, Agar Gel
- Exons
- Female
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Ovarian Neoplasms