Article
Nucleotide sequence of a human autoantibody to the alternative pathway C3/C5 convertase (C3NeF).
Hybridoma - 1 Jun 1993
Victor K D, Pascual V, Stitzel A E, Tsokos G C, Capra J D, Spitzer R E
Abstract excerpt
The production of autoantibodies to the alternative pathway C3/C5 convertase or C3 Nephritic Factor (C3NeF) is one characteristic of membranoproliferative glomerulonephritis. The complete nucleotide sequences of the heavy and light chain variable regions of an IgG C3NeF produced by an EBV transformed B cell line derived from a patient with membranoproliferative glomerulonephritis were determined. The VH and VL...
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