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Article

The majority of human tonsillar CD5+ B cells express somatically mutated V kappa 4 genes.

European journal of immunology - 1 Jun 1993

Ebeling S B, Schutte M E, Logtenberg T

Abstract excerpt

We have fractionated human tonsillar B cells on the basis of CD5 expression and determined the nucleotide sequences of immunoglobin light chain variable (V) regions encoded by the single member of the V chi 4 gene family in both CD5+ and CD5- populations. The majority of cDNA from both CD5+ and CD5- B cells populations harbored somatic mutations. Thus, human tonsillar CD5+ B cells, unlike their murine...

Topics

Amino Acid Sequence
Antigens, CD
B-Lymphocyte Subsets
Base Sequence
CD5 Antigens
Genes, Immunoglobulin
Humans
Immunoglobulin Variable Region
Immunoglobulin kappa-Chains
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligodeoxyribonucleotides

Palatine Tonsil

Polymerase Chain Reaction

Sequence Alignment

Source

Identifiers

PMID: 7684690
DOI: 10.1002/eji.1830230636

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7684690-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The majority of human tonsillar CD5+ B cells express somatically mutated V kappa 4 genes.PMID 7684690Read ↗

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