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Article

Third complementarity-determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than non-mutated genes.

Immunology - 1 Jun 2001

Rosner K, Winter D B, Tarone R E, Skovgaard G L, Bohr V A, Gearhart P J

Abstract excerpt

The third complementarity-determining region (CDR3) of immunoglobulin variable genes for the heavy chain (VH) has been shown to be shorter in length in hypermutated antibodies than in non-hypermutated antibodies. To determine which components of CDR3 contribute to the shorter length, and if there is an effect of age on the length, we analysed 235 cDNA clones from human peripheral blood of VH6 genes rearranged to...

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Identifiers

PMID: 11412305
DOI: 10.1046/j.1365-2567.2001.01220.x
PMCID: PMC1783224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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