Human anti-Gal heavy chain genes. Preferential use of VH3 and the presence of somatic mutations.

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Article

Human anti-Gal heavy chain genes. Preferential use of VH3 and the presence of somatic mutations.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 1995

Wang L, Radic M Z, Galili U

Abstract excerpt

Anti-Gal is the most abundant natural Ab known in humans. It interacts specifically with the carbohydrate structure Gal alpha 1-3 Gal beta 1-4GlcNAc-R (termed the alpha-galactosyl epitope), constitutes approximately 1% of circulating Ig, and is found in all three isotypes in the serum. Anti-Gal i...

Topics

Amino Acid Sequence
Animals
Antibodies, Heterophile
Antibodies, Monoclonal
Base Sequence
Carbohydrate Sequence
Cell Line, Transformed
Epitopes
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Genes, Immunoglobulin
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunity, Innate

Immunoglobulin Heavy Chains

Immunoglobulin Variable Region

Molecular Sequence Data

Mutation

Primates

Sequence Alignment

Source

Open in PubMed

Identifiers

PMID: 7543518

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7543518-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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