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Article

Complete amino acid sequence of the variable regions of two highly related heavy and light chains of human IgG (SFL) and IgM (RIV) rheumatoid factors.

Scandinavian journal of immunology - 1 Jun 1992

Newkirk M M

Abstract excerpt

The complete amino acid structure of the variable regions of two monoclonal human rheumatoid factors (RF), antibodies that bind to the Fc portion of IgG, is presented. Although these RFs are of different isotypes, IgG (SFL) and IgM (RIV), they are highly related. They probably derive from the same KIII light chain variable region used, but the heavy chains are derived from genes of the VHIII family that are...

Topics

Amino Acid Sequence
Cryoglobulinemia
Humans
Immunoglobulin G
Immunoglobulin Heavy Chains
Immunoglobulin Idiotypes
Immunoglobulin Light Chains
Immunoglobulin M
Immunoglobulin Variable Region
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Peptide Mapping

Purpura, Hyperglobulinemic

Rheumatoid Factor

Source

Identifiers

PMID: 1604239
DOI: 10.1111/j.1365-3083.1992.tb02971.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1604239-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Complete amino acid sequence of the variable regions of two highly related heavy and light chains of human IgG (SFL) and IgM (RIV) rheumatoid factors.PMID 1604239Read ↗

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