Article
The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidence that some autoantibodies are unmutated copies of germ line genes.
The Journal of clinical investigation - 1 Oct 1990
Pascual V, Randen I, Thompson K, Sioud M, Forre O, Natvig J, Capra J D
Abstract excerpt
Structural studies of human monoclonal rheumatoid factors (RF) derived from patients with monoclonal gammapathies have revealed a restriction in the usage of heavy and light chain variable regions. These studies have suggested that germline genes with little if any somatic mutation can generate R...
Topics
- Arthritis, Rheumatoid
- Autoantibodies
- B-Lymphocytes
- Base Sequence
- Genes, Immunoglobulin
- Herpesvirus 4, Human
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin J-Chains
- Immunoglobulin Variable Region
- Molecular Sequence Data
- Mutation