Article
Somatic mutations in the variable regions of a human IgG anti-double-stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus.
The Journal of experimental medicine - 1 Feb 1991
van Es J H, Gmelig Meyling F H, van de Akker W R, Aanstoot H, Derksen R H, Logtenberg T
Abstract excerpt
The processes that govern the generation of pathogenic anti-DNA autoantibodies in human systemic lupus erythematosus (SLE) are largely unknown. Autoantibodies may arise as a consequence of polyclonal B cell activation and/or antigen-driven B cell activation and selection. The role of these proces...
Topics
- Amino Acid Sequence
- Antibodies, Antinuclear
- Antibodies, Monoclonal
- B-Lymphocytes
- Base Sequence
- Cell Line, Transformed
- DNA
- Humans
- Immunoglobulin G
- Immunoglobulin Heavy Chains
- Immunoglobulin Idiotypes
- Immunoglobulin Light Chains
- Immunoglobulin Variable Region