Article
Molecular analysis of V kappa III variable regions of polyclonal rheumatoid factors during rheumatoid arthritis.
European journal of immunology - 1 May 1991
Blaison G, Kuntz J L, Pasquali J L
Abstract excerpt
We report the first molecular characterization of V kappa regions of the main human autoantibodies occurring during rheumatoid arthritis, the polyclonal rheumatoid factors. Using two sets of polymerase chain reactions in order to amplify the cDNA derived from both peripheral blood and synovial fl...
Topics
- Amino Acid Sequence
- Arthritis, Rheumatoid
- Base Sequence
- Cell Fractionation
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Variable Region
- Immunoglobulin kappa-Chains
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Rheumatoid Factor