Article
DNA hypermethylation is associated with 17p allelic loss in neural tumors.
Cancer research - 15 Jun 1993
Makos M, Nelkin B D, Chazin V R, Cavenee W K, Brodeur G M, Baylin S B
Abstract excerpt
It has long been debated whether the accumulation of allelic losses in tumors involves the selection of cells which have stochastically lost chromosomal regions or whether there is, inherent to the neoplastic state, a process which predisposes to genetic instability. Changes in DNA methylation are commonly seen in human tumors and can alter chromosome structure. We now have examined specific types of primary...
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