Article
Chromosome 17 allelic loss in astrocytic tumors and its clinico-pathologic implications.
Clinical neuropathology - 1 Jan 2000
Muhammad A K, Yoshimine T, Maruno M, Tokiyoshi K, Takemoto O, Ninomiya H, Hayakawa T
Abstract excerpt
To prognosticate the implications of various allelic losses on chromosome 17 in the morphology and biology of astrocytic tumors, we have examined loss of heterozygosity (LOH) at 14 microsatellite loci on chromosome 17 in a series of 19 astrocytic tumors (3 astrocytomas, 5 anaplastic astrocytomas, and 11 glioblastomas). The DNA samples extracted from tumor and matched normal brain tissue were amplified by...
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