Definition of regions of the human genome affected by loss of heterozygosity in primary human breast tumors.

doi:10.1002/jcb.240531131

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Article

Definition of regions of the human genome affected by loss of heterozygosity in primary human breast tumors.

Journal of cellular biochemistry. Supplement - 1 Jan 1993

Callahan R, Cropp C, Sheng Z M, Merlo G, Steeg P, Liscia D, Lidereau R

Abstract excerpt

We have undertaken a systematic study of primary human breast tumor DNA to identify and characterize frequently occurring somatic mutations. Loss of heterozygosity (LOH) has been the most frequent mutation in our panels of primary breast tumor DNA. It is currently thought that LOH reveals recessi...

Topics

Breast Neoplasms
Chromosome Mapping
Chromosomes, Human, Pair 17
Female
Gene Deletion
Genome, Human
Heterozygote
Humans
Mutation

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