Article
Deletion of chromosome 17p loci in breast cancer cells detected by fluorescence in situ hybridization.
Cancer research - 15 Jun 1992
Matsumura K, Kallioniemi A, Kallioniemi O, Chen L, Smith H S, Pinkel D, Gray J, Waldman F M
Abstract excerpt
Allelic loss of tumor suppressor genes on chromosome 17p has been implicated in the progression of breast cancer. This is in principle detectable by fluorescence in situ hybridization if the loss occurs by deletion. In order to determine if detectable deletions occur in primary breast cancer, we used dual-color hybridization with chromosome 17 pericentromeric and region-specific DNA probes to study 19 primary...
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