Genetic alterations on chromosome 17 in human breast cancer: relationships to clinical features and DNA ploidy.

doi:10.1007/BF00666584

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Article

Genetic alterations on chromosome 17 in human breast cancer: relationships to clinical features and DNA ploidy.

Breast cancer research and treatment - 1 Dec 1993

Watatani M, Nagayama K, Imanishi Y, Kurooka K, Wada T, Inui H, Hirai K, Ozaki M, Yasutomi M

Abstract excerpt

We analyzed DNA from 105 primary breast cancers to assess amplification of the ERBB2 gene and loss of heterozygosity (LOH) on chromosome 17 using 4 polymorphic markers, and investigated the relationships of these genetic alterations to clinicopathological characteristics including DNA ploidy. Amp...

Topics

Alleles
Breast Neoplasms
Chromosome Aberrations
Chromosome Deletion
Chromosomes, Human, Pair 17
DNA Probes
DNA, Neoplasm
ErbB Receptors
Female
Gene Amplification
Genetic Variation
Humans
Ploidies
Prognosis
Proto-Oncogene Proteins
Receptor, ErbB-2

Source

Open in PubMed

Identifiers

PMID: 7912561
DOI: 10.1007/BF00666584

Genes

NME1
ERBB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7912561-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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