Article
Regional DNA hypermethylation at D17S5 precedes 17p structural changes in the progression of renal tumors.
Cancer research - 15 Jun 1993
Makos M, Nelkin B D, Reiter R E, Gnarra J R, Brooks J, Isaacs W, Linehan M, Baylin S B
Abstract excerpt
In a preceding paper for brain tumors, we demonstrate a tight association between regional hypermethylation at locus D17S5 of chromosome 17p and allelic loss of this chromosome. Because 17p allelic losses occur at the earliest stages of brain tumors, the exact temporal relationship between this event and the hypermethylation could not be elucidated. In renal cancers, two linked structural changes on chromosome...
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