Article
Pediatric brain tumors: loss of heterozygosity at 17p and TP53 gene mutations.
Cancer genetics and cytogenetics - 15 Apr 1998
Orellana C, Hernandez-Martí M, Martínez F, Castel V, Millán J M, Alvarez-Garijo J A, Prieto F, Badía L
Abstract excerpt
Cytogenetic and molecular analyses of primitive neuroectodermal tumors (PNETs) of the central nervous system (CNS) have demonstrated material losses of 17p, the region that contains the TP53 gene, as the most frequent abnormality. Mutations in the TP53 gene are, however, very rare in these tumors. These findings strongly suggest that another, as yet unidentified, gene on 17p may be involved. We performed a search...
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