Pediatric brain tumors: loss of heterozygosity at 17p and TP53 gene mutations.

doi:10.1016/s0165-4608(97)00343-9

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Article

Pediatric brain tumors: loss of heterozygosity at 17p and TP53 gene mutations.

Cancer genetics and cytogenetics - 15 Apr 1998

Orellana C, Hernandez-Martí M, Martínez F, Castel V, Millán J M, Alvarez-Garijo J A, Prieto F, Badía L

Abstract excerpt

Cytogenetic and molecular analyses of primitive neuroectodermal tumors (PNETs) of the central nervous system (CNS) have demonstrated material losses of 17p, the region that contains the TP53 gene, as the most frequent abnormality. Mutations in the TP53 gene are, however, very rare in these tumors...

Topics

Adolescent
Adult
Astrocytoma
Brain Neoplasms
Child
Child, Preschool
Chromosomes, Human, Pair 17
Ependymoma
Female
Ganglioglioma
Genes, Tumor Suppressor
Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glioblastoma

Humans

Infant

Infant, Newborn

Loss of Heterozygosity

Male

Source

Open in PubMed

Identifiers

PMID: 9546059
DOI: 10.1016/s0165-4608(97)00343-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9546059-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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