An OspB mutant of Borrelia burgdorferi has reduced invasiveness in vitro and reduced infectivity in vivo.

doi:10.1128/iai.61.9.3590-3596.1993

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Article

An OspB mutant of Borrelia burgdorferi has reduced invasiveness in vitro and reduced infectivity in vivo.

Infection and immunity - 1 Sept 1993

Sadziene A, Barbour A G, Rosa P A, Thomas D D

Abstract excerpt

Most Borrelia burgdorferi strains have two major surface proteins, OspA and OspB. In the present study, we selected from a clonal population of infectious B. burgdorferi an OspB escape mutant, identified the genetic basis for this phenotype, and evaluated its functional activities. Selection with...

Topics

Amino Acid Sequence
Animals
Antigens, Bacterial
Antigens, Surface
Bacterial Outer Membrane Proteins
Base Sequence
Borrelia burgdorferi Group
Humans
Mice
Molecular Sequence Data
Mutation
Virulence

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