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Article

An OspB mutant of Borrelia burgdorferi has reduced invasiveness in vitro and reduced infectivity in vivo.

Infection and immunity - 1 Sept 1993

Sadziene A, Barbour A G, Rosa P A, Thomas D D

Abstract excerpt

Most Borrelia burgdorferi strains have two major surface proteins, OspA and OspB. In the present study, we selected from a clonal population of infectious B. burgdorferi an OspB escape mutant, identified the genetic basis for this phenotype, and evaluated its functional activities. Selection with the anti-OspB antibody H614 was performed in vitro in medium and extended in vivo in scid mice. Mutants with a...

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Identifiers

PMID: 8359881
DOI: 10.1128/iai.61.9.3590-3596.1993
PMCID: PMC281052

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