Article
Four clones of Borrelia burgdorferi sensu stricto cause invasive infection in humans.
Infection and immunity - 1 Jul 1999
Seinost G, Dykhuizen D E, Dattwyler R J, Golde W T, Dunn J J, Wang I N, Wormser G P, Schriefer M E, Luft B J
Abstract excerpt
Lyme disease begins at the site of a tick bite, producing a primary infection with spread of the organism to secondary sites occurring early in the course of infection. A major outer surface protein expressed by the spirochete early in infection is outer surface protein C (OspC). In Borrelia burgdorferi sensu stricto, OspC is highly variable. Based on sequence divergence, alleles of ospC can be divided into 21...
Topics
- Antigens, Bacterial
- Bacterial Outer Membrane Proteins
- Borrelia burgdorferi
- Borrelia burgdorferi Group
- Genes, Bacterial
- Genetic Variation
- Humans
- Lyme Disease
- Virulence
