Article
Outer surface protein B is critical for Borrelia burgdorferi adherence and survival within Ixodes ticks.
PLoS pathogens - 1 Mar 2007
Neelakanta Girish, Li Xin, Pal Utpal, Liu Xianzhong, Beck Deborah S, DePonte Kathleen, Fish Durland, Kantor Fred S, Fikrig Erol
Abstract excerpt
Survival of Borrelia burgdorferi in ticks and mammals is facilitated, at least in part, by the selective expression of lipoproteins. Outer surface protein (Osp) A participates in spirochete adherence to the tick gut. As ospB is expressed on a bicistronic operon with ospA, we have now investigated the role of OspB by generating an OspB-deficient B. burgdorferi and examining its phenotype throughout the spirochete...
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