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Article

Abrogation of ospAB constitutively activates the Rrp2-RpoN-RpoS pathway (sigmaN-sigmaS cascade) in Borrelia burgdorferi.

Molecular microbiology - 1 Dec 2008

He Ming, Oman Tara, Xu Haijun, Blevins Jon, Norgard Michael V, Yang X Frank

Abstract excerpt

Molecular mechanisms underlying the reciprocal regulation of the two major surface lipoproteins and virulence factors of Borrelia burgdorferi, OspA and OspC, are not fully understood. Herein, we report that inactivation of the ospAB operon resulted in overproduction of OspC and many other lipoproteins via the constitutive activation of the Rrp2-RpoN-RpoS pathway. Complementing the ospAB mutant with a wild-type...

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Identifiers

PMID: 19019147
DOI: 10.1111/j.1365-2958.2008.06491.x
PMCID: PMC2792205

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Abrogation of ospAB constitutively activates the Rrp2-RpoN-RpoS pathway (sigmaN-sigmaS cascade) in Borrelia burgdorferi.PMID 19019147Read ↗

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