Article
Recombination between genes encoding major outer surface proteins A and B of Borrelia burgdorferi.
Molecular microbiology - 1 Oct 1992
Rosa P A, Schwan T, Hogan D
Abstract excerpt
Borrelia burgdorferi causes Lyme disease, a multisystem illness that can persist in humans for many years. We describe recombination between homologous genes encoding the major outer surface proteins (Osps) A and B of B. burgdorferi which both deletes osp gene sequences and creates chimaeric gene fusions. Recombinant osp genes occur in multiple strains and encode unique proteins that lack some characteristic Osp...
Topics
- Amino Acid Sequence
- Antigenic Variation
- Antigens, Bacterial
- Antigens, Surface
- Bacterial Outer Membrane Proteins
- Bacterial Vaccines
- Base Sequence
- Borrelia burgdorferi Group
- Gene Amplification
- Genes, Bacterial
- Genetic Variation