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Article

Outer surface protein C is a dissemination-facilitating factor of Borrelia burgdorferi during mammalian infection.

PloS one - 31 Dec 2010

Seemanapalli Sunita V, Xu Qilong, McShan Kristy, Liang Fang Ting

Abstract excerpt

BACKGROUND: The Lyme disease spirochete Borrelia burgdorferi dramatically upregulates outer surface protein C (OspC) in response to fresh bloodmeal during transmission from the tick vector to a mammal, and abundantly produces the antigen during early infection. As OspC is an effective immune target, to evade the immune system B. burgdorferi downregulates the antigen once the anti-OspC humoral response has...

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Share to Antigens, Bacterial
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Share to Fluorescent Antibody Technique, Indirect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Immunity, Humoral

Share to Mice, Inbred C3H

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Source

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Identifiers

PMID: 21209822
DOI: 10.1371/journal.pone.0015830
PMCID: PMC3013124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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