Article
Selection of variant Borrelia burgdorferi isolates from mice immunized with outer surface protein A or B.
Infection and immunity - 1 May 1995
Fikrig E, Tao H, Barthold S W, Flavell R A
Abstract excerpt
A nonclonal population of Borrelia burgdorferi N40 (passage 3) that survived protective immunity following challenge inoculation of outer surface protein (Osp) A- or B-hyperimmunized mice were characterized for the molecular basis of evasion of immunity. Two of six B. burgdorferi isolates, cultur...
Topics
- Animals
- Antigens, Bacterial
- Antigens, Surface
- Bacterial Outer Membrane Proteins
- Bacterial Vaccines
- Borrelia burgdorferi Group
- Cloning, Molecular
- Female
- Genes, Bacterial
- Genetic Variation
- Immunoblotting
- Lipoproteins
- Lyme Disease
- Mice
- Mice, Inbred C3H
- Recombinant Proteins
- Selection, Genetic
- Sequence Analysis, DNA