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Article

Antibody-resistant mutants of Borrelia burgdorferi: in vitro selection and characterization.

The Journal of experimental medicine - 1 Sept 1992

Sădziene A, Rosa P A, Thompson P A, Hogan D M, Barbour A G

Abstract excerpt

We used polyclonal antisera and monoclonal antibodies (mAbs) to inhibit the growth of clonal populations of two strains of Borrelia burgdorferi, the Lyme disease agent, and thereby select for antibody-resistant mutants. mAbs were directed at the outer membrane proteins, OspA or OspB. Mutants resistant to the growth-inhibiting properties of the antibodies were present in the populations at frequencies ranging from...

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Identifiers

PMID: 1339462
DOI: 10.1084/jem.176.3.799
PMCID: PMC2119346

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