Correlation between p53 mutations and antibody staining in breast carcinoma.

doi:10.1002/bjs.1800801118

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Article

Correlation between p53 mutations and antibody staining in breast carcinoma.

The British journal of surgery - 1 Nov 1993

Dunn J M, Hastrich D J, Newcomb P, Webb J C, Maitland N J, Farndon J R

Abstract excerpt

Abnormalities of the p53 gene and protein were examined in 81 primary breast carcinoma samples. Using a polymerase chain reaction-single-strand conformational polymorphism (PCR-SSCP) analysis, mutations in p53 exons 5-8 were identified in 13 of 81 tumours (16 per cent) and confirmed by DNA sequen...

Topics

Adult
Aged
Aged, 80 and over
Base Sequence
Breast Neoplasms
DNA, Neoplasm
ErbB Receptors
Female
Genes, p53
Humans
Immunohistochemistry
Middle Aged
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Tumor Suppressor Protein p53

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