Loss of heterozygosity and p53 gene mutations in breast cancer.

Article

Loss of heterozygosity and p53 gene mutations in breast cancer.

Cancer research - 15 Jan 1994

Deng G, Chen L C, Schott D R, Thor A, Bhargava V, Ljung B M, Chew K, Smith H S

Abstract excerpt

Immunopositivity for the p53 tumor suppressor gene product was evaluated in 133 breast cancers and compared to loss of heterozygosity (LOH) at various chromosomal loci. The validity of p53 immunopositivity as an indicator for p53 mutations was verified using two molecular assays of p53 mutations:...

Topics

Base Sequence
Breast Neoplasms
Carcinoma
Carcinoma, Ductal, Breast
Carcinoma, Lobular
Chromosome Deletion
DNA, Neoplasm
Genes, p53
Heterozygote
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Sequence Analysis, DNA

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