Comparison of p53 gene mutation and protein overexpression in colorectal carcinomas.

doi:10.1038/bjc.1994.355

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Article

Comparison of p53 gene mutation and protein overexpression in colorectal carcinomas.

British journal of cancer - 1 Oct 1994

Dix B, Robbins P, Carrello S, House A, Iacopetta B

Abstract excerpt

Immunocytochemistry (ICC) has been used routinely to stain for p53 overexpression in a range of human tumours. The underlying assumption has been that positive staining indicates a mutation in the p53 coding sequence. Recently, however, discordancy has been observed and the accuracy of ICC as a m...

Topics

Antibodies, Monoclonal
Base Sequence
Colorectal Neoplasms
DNA, Neoplasm
Gene Expression
Genes, p53
Humans
Immunohistochemistry
Molecular Sequence Data
Mutation
Polymorphism, Single-Stranded Conformational
Tumor Suppressor Protein p53

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