Article
Concordance between p53 protein overexpression and gene mutation in a large series of common human carcinomas.
Human pathology - 1 Oct 1996
Soong R, Robbins P D, Dix B R, Grieu F, Lim B, Knowles S, Williams K E, Turbett G R, House A K, Iacopetta B J
Abstract excerpt
Immunohistochemical (IHC) detection of p53 protein was compared with the presence of p53 gene mutation in many colorectal (n = 100), breast (n = 92), endometrial (n = 122), and gastric (n = 116) carcinomas. Two commercially available antibodies, DO7 and CM1, were used for IHC analysis of paraffin...
Topics
- Breast Neoplasms
- Carcinoma
- Colorectal Neoplasms
- Endometrial Neoplasms
- Female
- Humans
- Immunohistochemistry
- Linkage Disequilibrium
- Mutation
- Polymerase Chain Reaction
- Reproducibility of Results
- Stomach Neoplasms
- Tumor Suppressor Protein p53
- Up-Regulation