Article
Mutant p53, EGF receptor and c-erbB-2 expression in human breast cancer.
Oncogene - 1 Dec 1991
Horak E, Smith K, Bromley L, LeJeune S, Greenall M, Lane D, Harris A L
Abstract excerpt
p53 expression was studied in 111 primary breast cancers with a monoclonal antibody (PAb240) that reacts with an epitope in mutant p53. Epidermal growth factor receptors (EGFr) and oestrogen receptors (ER) measured by ligand binding, c-erbB-2 expression assessed by immunochemistry and lymph node status were compared with p53 staining. Fifty-nine tumours (53%) were positive for p53, and this correlated with EGFr...
Topics
- Biomarkers, Tumor
- Breast Neoplasms
- ErbB Receptors
- Female
- Gene Amplification
- Humans
- Immunohistochemistry
- Mutation
- Proto-Oncogene Proteins
- Receptor, ErbB-2
- Receptors, Estrogen