p53 protein accumulation and mutations in normal and benign breast tissue.

Abstract excerpt

Mutations in the p53 gene are amongst the most common molecular changes detected in breast cancer, and there are several reports suggesting that changes in p53 may contribute to the pathogenesis of this disease. In a previous case-control study, we demonstrated that p53 protein accumulation detected by immunohistochemistry in normal or benign breast tissue was associated with a 2.5-fold increase in the risk of...

Topics

• Breast
• Breast Neoplasms
• Exons
• Female
• Genes, p53
• Humans
• Immunohistochemistry
• Mutation
• Mutation, Missense
• Point Mutation
• Polymerase Chain Reaction
• Polymorphism, Single-Stranded Conformational