Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Accumulation of p53 protein as an indicator for p53 gene mutation in breast cancer. Occurrence of false-positives and false-negatives.

Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Mar 1993

Lohmann D, Ruhri C, Schmitt M, Graeff H, Höfler H

Abstract excerpt

Accumulation of p53 protein resulting in levels detectable by immunohistochemistry (IHC) has been proposed as an indicator of mutation of the p53 gene. We have investigated a panel of 23 fresh-frozen breast cancers by IHC (PAb 1801), Southern and Northern blot analysis, and direct sequencing of the mutation hot spot regions (exons 5-8) of the p53 gene. Three tumors (13%) showed an intense nuclear staining in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Blotting, Northern

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Blotting, Southern

Share to DNA Mutational Analysis

Share to Genes, p53

Share to Immunohistochemistry

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 8287224

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Accumulation of p53 protein as an indicator for p53 gene mutation in breast cancer. Occurrence of false-positives and false-negatives.PMID 8287224Read ↗

p53 protein accumulation and mutations in normal and benign breast tissue.Semantic proximity Read ↗

Accumulation of p53 tumor suppressor gene protein: an independent marker of prognosis in breast cancers.Semantic proximity Read ↗

Genetic basis for p53 overexpression in human breast cancer.Semantic proximity Read ↗

A comparison between p53 accumulation determined by immunohistochemistry and<i>TP53</i>mutations as prognostic variables in tumours from breast cancer patientsSemantic proximity Read ↗

Association among p53 gene mutation, nuclear accumulation of the p53 protein and aggressive phenotypes in breast cancer.Semantic proximity Read ↗

Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies.Semantic proximity Read ↗

p53 accumulation and mutation are prognostic indicators of poor survival in human gastric carcinoma.Semantic proximity Read ↗

Analysis of p53 mutation and cyclin D1 expression in breast tumors.Semantic proximity Read ↗

Correlation between mutations in p53 gene and protein expression in human lymphomas.Semantic proximity Read ↗

p53 protein expression in non-Hodgkin's lymphomas is infrequently related to p53 gene mutations.Semantic proximity Read ↗

The effect of immunohistochemically detected p53 accumulation in prognosis of breast cancer; A retrospective survey of outcome.Semantic proximity Read ↗

High levels of p53 protein expression do not correlate with p53 gene mutations in anaplastic large cell lymphoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.