Article
Identification of p53 mutations by means of single strand conformation polymorphism analysis in gynaecological tumours: comparison with the results of immunohistochemistry.
European journal of cancer (Oxford, England : 1990) - 1 Jan 1994
Schneider J, Rubio M P, Rodriguez-Escudero F J, Seizinger B R, Castresana J S
Abstract excerpt
The tumour-suppressing gene p53 may undergo mutation by a variety of mechanisms, thus losing its tumour-suppressing activity, and ultimately behaving like an oncogene. The PAb 1801 monoclonal antibody is known to recognise both wild type and mutated p53, although in practice it seems to show a higher reactivity with the mutated gene product in several human tumours. We studied p53 overexpression in a series of 36...
Topics
- Base Sequence
- Breast Neoplasms
- DNA, Neoplasm
- Female
- Genes, p53
- Humans
- Immunoenzyme Techniques
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction