Wild type p53 functions as a control protein in the differentiation pathway of the B-cell lineage.

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Article

Wild type p53 functions as a control protein in the differentiation pathway of the B-cell lineage.

Oncogene - 1 Dec 1993

Aloni-Grinstein R, Zan-Bar I, Alboum I, Goldfinger N, Rotter V

Abstract excerpt

An analysis of cell lines representing different stages of the B-cell differentiation pathway indicated that about 50% of the cell lines examined expressed exclusively wild type p53 protein. These lines therefore offer a convenient system to study the involvement of p53 in cell differentiation. When 70Z/3, a pre-B cell line which expresses wild type p53, was treated with the differentiation inducer...

Topics

Animals
B-Lymphocytes
Base Sequence
Cell Differentiation
Cell Line, Transformed
Cell Transformation, Neoplastic
Chloramphenicol O-Acetyltransferase
DNA, Neoplasm
Gene Expression
Immunoglobulin A
Immunoglobulin kappa-Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lipopolysaccharides

Mice

Molecular Sequence Data

Mutation

Plasmacytoma

Plasmids

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 8247532

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8247532-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Wild type p53 functions as a control protein in the differentiation pathway of the B-cell lineage.PMID 8247532Read ↗

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