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Article

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6.

Nature - 25 Jul 1991

Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A, Oren M

Abstract excerpt

Wild-type p53 protein has many properties consistent with its being the product of a tumour suppressor gene. Although the normal roles of tumour suppressor genes are still largely unknown, it seems that they could be involved in promoting cell differentiation as well as in mediating growth arrest by growth-inhibitory cytokines. Hence, the abrogation of wild-type p53 expression, which is a common feature of many...

Topics

Animals
Cell Differentiation
Cell Survival
Genes, p53
Interleukin-6
Leukemia, Myeloid
Mice
Mutation
Transfection
Tumor Cells, Cultured
Tumor Suppressor Protein p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1852210
DOI: 10.1038/352345a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1852210-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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