Article
The tumor suppressor gene p53 can mediate transforming growth [corrected] factor beta1-induced differentiation of leukemic cells independently of activation of the retinoblastoma protein.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Oct 1997
Ehinger M, Bergh G, Johnsson E, Gullberg U, Olsson I
Abstract excerpt
Although the involvement of the tumor suppressor gene p53 in normal hematopoiesis is uncertain, it can give rise to differentiation signals in leukemic cells. It is not clear, however, whether differentiation merely is a consequence of the ability of p53 to arrest cell proliferation or whether hi...
Topics
- Apoptosis
- Cell Differentiation
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Dose-Response Relationship, Drug
- Genes, p53
- Humans
- Leukemia
- Leukocytes
- Mutation
- Phosphorylation
- Retinoblastoma Protein
- Temperature
- Transfection