Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two different IFN-gamma nonresponsive variants derived from the B-cell lymphoma 70Z/3.

Immunogenetics - 1 Jan 1994

Rhodes L D, Paull A T, Sibley C H

Abstract excerpt

The kappa immunoglobulin (Igk) light chain locus is transcriptionally silent in the mouse B-cell lymphoma 70Z/3. However, exposure to lipopolysaccharide (LPS) or interferon-gamma (IFN) causes a marked increase in Igk transcription. By immunoselection, we isolated two variants that are nonresponsive to IFN. One variant, AT7.2, has retained its response to LPS (IFN-LPS+), whereas the other, AT3.3, is also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to Base Sequence
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Molecular Sequence Data

Share to Protein Binding

Share to Signal Transduction

Source

Identifiers

PMID: 8039828
DOI: 10.1007/BF00167080

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two different IFN-gamma nonresponsive variants derived from the B-cell lymphoma 70Z/3.PMID 8039828Read ↗

Lipopolysaccharide-unresponsive mutant pre-B-cell lines blocked in NF-kappa B activation.Semantic proximity Read ↗

Expression of CD14 corrects the slow response to lipopolysaccharide in the 1B8 mutant of the B cell lymphoma 70Z/3.Semantic proximity Read ↗

TRAF-3 mRNA splice-deletion variants encode isoforms that induce NF-kappaB activation.Semantic proximity Read ↗

Differentiation of murine pre-B cell line by an adjuvant muramyl peptide via NF-kappa B activation.Semantic proximity Read ↗

A mutant cell line partially responsive to both IFN-alpha and IFN-gamma.Semantic proximity Read ↗

Characterization of a mutant cell line that does not activate NF-kappaB in response to multiple stimuli.Semantic proximity Read ↗

NF-kappaB elements associated with the Stat6 site in the germline gamma1 immunoglobulin promoter are not necessary for the transcriptional response to CD40 ligand.Semantic proximity Read ↗

B-cell receptor- and phorbol ester-induced NF-kappaB and c-Jun N-terminal kinase activation in B cells requires novel protein kinase C's.Semantic proximity Read ↗

Construction of a lipopolysaccharide reporter cell line and its use in identifying mutants defective in endotoxin, but not TNF-alpha, signal transduction.Semantic proximity Read ↗

The 3' Igkappa enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic kappa gene expression.Semantic proximity Read ↗

Impaired IgE response in SWAP-70-deficient mice.Semantic proximity Read ↗

Wild type p53 functions as a control protein in the differentiation pathway of the B-cell lineage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.