Article
Lipopolysaccharide-unresponsive mutant pre-B-cell lines blocked in NF-kappa B activation.
Molecular and cellular biology - 1 Jan 1990
Briskin M, Damore M, Law R, Lee G, Kincade P W, Sibley C H, Kuehl M, Wall R
Abstract excerpt
NF-kappa B activation is a crucial late step in the induction of immunoglobulin kappa light-chain gene expression in pre-B cells by lipopolysaccharide (LPS). We have analyzed NF-kappa B activation in three independent mutant lines of 70Z/3 pre-B cells which are unresponsive to LPS. All three vari...
Topics
- Animals
- B-Lymphocytes
- Gene Expression Regulation
- Gene Rearrangement
- Genes, Immunoglobulin
- Immunoglobulin kappa-Chains
- In Vitro Techniques
- Lipopolysaccharides
- Lymphocyte Activation
- Mice
- Mutation
- NF-kappa B
- Tetradecanoylphorbol Acetate
- Transcription Factors
- Transcriptional Activation