Article
p53 is a regulator of macrophage differentiation.
Cell death and differentiation - 1 Apr 2004
Matas D, Milyavsky M, Shats I, Nissim L, Goldfinger N, Rotter V
Abstract excerpt
While it is well accepted that p53 plays a role in apoptosis, less is known as to its involvement in cell differentiation. Here we show that wild-type p53 facilitates IL-6-dependent macrophage differentiation. Treatment of M1/2 cells expressing the temperature-sensitive p53 143 (Val to Ala) mutant, at the wild-type conformation, facilitated the appearance of mature macrophages that exhibited phagocytic activity....
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